Tiredness, frenetic rhythms, stress, smoke, pollution, an intense exposure to external agents (sun, wind) increase the accumulation of toxins and reduce the vascularity and the supply of oxygen to the skin tissues that, no longer able to breathe, begin to suffer from “cellular fatigue” . They are less able to produce energy, to renew and to activate the defense systems against free radicals and other factors of aging. This deoxygenated and tired skin becomes dull and gray, and it will early encounter wrinkles, spots, and impurities.